Fort Selkirk is a former trading post on the Yukon River at the confluence of the Pelly River in Canada's Yukon. For many years it was home to the Selkirk First Nation (Northern Tutchone).
Archaeological evidence shows that the site has been in use for at least 8,000 years. Robert Campbell established a Hudson's Bay Company trading post nearby in 1848. In early 1852 he moved the post to its current location. Resenting the interference of the Hudson's Bay Company with their traditional trade with interior Athabaskan First Nations, Chilkat Tlingit warriors attacked and looted the post that summer. It was rebuilt about 40 years later and became an important supply point along the Yukon River. It was essentially abandoned by the mid-1950s after the Klondike Highway bypassed it and Yukon River traffic died down.